Publications

Year Title Journal
2016 Safety and long-term effect of the probiotic FK-23 in patients with hepatitis C virus infection BMFH
Combined Effect of Lysed Enterococcus faecalis FK-23 and Fruits of Citrus unshiu on Contact Dermatitis in Mice Pharmacometrics
Enterococcus durans TN-3 Induces Regulatory T Cells and Suppresses the Development of Dextran Sulfate Sodium (DSS)-Induced Experimental Colitis PLOS ONE
2014 Beneficial effects of heat-treated Enterococcus faecalis FK-23 on high-fat diet-induced hepatic steatosis in mice. British Journal of Nutrition
2013 Enterococcus faecalis FK-23 affects alveolar-capillary permeability to attenuate leukocyte influx in lung after influenza virus infection Springer Plus
2012 Lactic acid bacterial extract (LFK) suppresses Th17 cell response and attenuates allergic airway responses. International Journal of Molecular Medicine
Effect of LFK in an allergic rhinitis model in mice and its mechanism Journal of Biomedical Research
Effect of water-soluble fraction from lysozyme-treated Enterococcus faecalis FK-23 on mortality caused by influenza A virus in mice.
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Viral Immunology
2010 Confirmation of drug sensitivity and vancomycin-resistant gene of probiotic lactic acid bacteria Enterococcus faecalis FK-23
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Japanese Journal of Food Microbiology
Utility of Enterococcus faecalis FK-23 preparation on fatting of Japanese black cattle China Cattle Science
Enhancement of anti-allergic effect mediated by kampo medicine Shoseiryuto (Xiao-Qing-Long-Tang in Chinese) with lysed Enterococcus faecalis FK-23 in mice
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Asian pacific journal of allergy and immunology
Establishment of high sensitive enzyme-linked immunosorbent assay of major house dust mite allergen Der p 1/ Der f 1
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Allergy
2009 An assessment of the safety of foods containing heat-killed preparation of Enterococcus faecalis FK-23 in human Pharmacometrics
Anti-obese effect of lactic acid bacteria Enterococcus faecalis FK-23 in obese mice model induced by high-fat diets
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Journal of the Japanese Society for Food Science and Technology
Effect of Enterococcus sp. isolated from deep seawater on inhibition of allergic responses in mice British journal of nutrition
Anti-obese effect of fermented soymilk by Enterococcus faecalis TN-9 in ovariectomized rats
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Journal of the Japanese Society for Food Science and Technology
Immunomodulation effect of heat-treated Enterococcus faecalis FK-23 (FK-23) in mice Journal of Nanjing medical university
Purification and characterization of cold-adapted metalloprotease from deep sea water lactic acid bacteria Enterococcus faecalis TN-9
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International Journal of Biology
2008 Effect of lysed Enterococcus faecalis FK-23 on allergen-induced peritoneal accumulation of eosinophils and serum total IgE concentration in inbred mice
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Asian pacific journal of allergy and immunology
Improvement of vaccination effect on ocellate puffer and Japanese flounder by the feeding of artificial feed with heat-killed Enterococcus faecalis FK-23 Aquaculture science
Metabolism of soybean isoflavones by intestinal microbiota J Clinical and Experimental medicine
Subacute toxicity test of deep ocean water derived Enterococcus faecalis TN-3 Pharmacometrics
2007 An assessment of the safety of foods containing extracts of Enterococcus faecalis FK-23 (LFK) in human Pharmacometrics
Subacute toxicity test of deep ocean water derived Enterococcus faecalis TN-9 Pharmacometrics
Development of ELISA kit of major house dust mite allergens (Der p1/Der f1) Allergy in Practice
Isolation and characterization of lactic acid bacteria enterococci from deep ocean water in Toyama gulf Japanese Journal of Lactic Acid Bacteria
Development of major house dust mite allergen Der p1/Der f1 The Journal of Clinical Laboratory Instruments and Reagents
Effect of lysed Enterococcus faecalis FK-23 on allergen-induced immune responses and intestinal microflora in antibiotic-treated weaning mice
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J investg allergol clin immunol
2006 Prevention of allergic diseases by probiotics Progress in medicine
Lactic acid bacteria Enterococcus faecalis FK-23 as complementally alternative medicine New food industry
Development of ELISA kit of major cedar pollen allergen Cry j1 The Journal of Clinical Laboratory Instruments and Reagents
2005 Anti-allergic effect of heat-killed preparation of Enterococcus casseliflavus NF-1004 Allergy in Practice
Application of Enterococcus faecalis extracts (LFK) to cosmetic materials Fragrance journal
Lysed Enterococcus faecalis FK-23 (LFK) suppressing allergic responses in mouse models Allergology International
Subacute toxicity test of ethanol extracts of Enterococcus casseliflavus NF-1004 (NP-04) in rats Pharmacometrics
2004 Effect of afermented vegetable product on fat deposition and bone metabolism in ovariectomized rats
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Journal of nutritional science and vitaminology
Suppression of 5-Fluorouracil side-effects by oral administration of Enterococcus faecalis FK-23 preparation Journal of Japanese Red Cross Society Wakayama Medical Center
Improvement of serum transaminase leveling hepatitis C patients by oral intake of heat-killed Enterococcus faecalis FK-23 Journal of Japanese Red Cross Society Wakayama Medical Center
Lysed Enterococcus faecalis FK-23 oral administration reveals inverse association between tuberculin responses and clinical manifestations in perennial allergic rhinitis: a pilot study
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J Invest Allergol Clin Immunol
Analysis of interaction between gene and environmental life-style: occupational asthma model
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Allergy
Effect of lysed Enterococcus faecalis FK-23 on allergen-induced serum antibody responses and active cutaneous anaphylaxis in mice
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Clin exp allergy
2003 Effect of various preparation types of the Enterococcus faecalis FK-23 strain on the ability of eliciting tumor necrosis factor from macrophages isolated from mice Journal of Japanese Red Cross Society Wakayama Medical Center
Effect of Enterococcus faecalis FK-23 (LFK) on allergen-induced peritoneal accumulation of eosinophils in mice
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Clin exp allergy
2002 Clinical test of LFK (FK-23 extracts) against acne vulgaris Pharmacometrics
2001 Effect of Enterococcus faecalis FK-23 extracts (LFK) against rosacea Pharmacometrics
2000 Effect of LFK (FK-23 extracts) against ragweed antigen-induced eosinophils accumulation Prospect in Otolaryngology
Clinical test of granulated food containing LFK (FK-23 extracts) against cedar pollen-induced allergy Prospect in Otolaryngology
1998 Toxicity test in rats by oral administration of Enterococcus faecalis FK-23 in rats for 4 weeks Pharmacometrics
1997 Enhancing of TNF production and anti-tumor activity by amphotericin B agent Biotherapy
Augmentation of production of TNF-a and anti-tumor activity by an amphotericin B preparation for clinical use in mice
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British journal of cancer
Clinical test in mice and rats by oral administration of Enterococcus faecalis FK-23 extracts (LFK) Pharmacometrics
1996 Oral administration of Enterococcus faecalis FK-23 enhance the production of interferon in splenocyte and resistance to herpes simplex virus-1 infection
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Yakugaku Zasshi
Optimal dose of enterococcal preparation (FK-23) supplemented perorally for stimulation of leukocyte reconstitution in dogs treated with cyclophosphamide
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Journal of veterinary medical sciences
Effect of orally administrated heat-killed Enterococcus faecalis FK-23 preparation on neutropenia in dogs treated with cyclophosphamide
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International journal of immunopharmacology
Prophylactic effect of Enterococcus faecalis FK-23 preparation on experimental candidasis in mice
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Microbiology and immunology
Identification of an RNA fraction from Enterococcus faecalis FK-23 cells as the anti-hypertensive compound Journal of fermentation and bioengineering
1995 Enhancing of tumor-necrosis factor production in germ free mice by oral administration of heat-killed preparation of Enterococcus faecalis FK-23
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Journal of the Agricultural Chemical Society of Japan
Study on prevention and early diagnosis of intrinsic pseudomonas infection: Prevention effect of biological response modifiers in mice model and detection of antigens in blood Teikyo Medical Journal
1994 Effect of orally administrated heat-killed Enterococcus faecalis FK-23 preparation on leucopenia in mice treated with cyclophosphamide
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Journal of veterinary medical sciences
Fundamental examination and clinical test of heat-killed Enterococcus faecalis FK-23 Journal of Animal Clinical Medicine
1993 Lactic acid bacteria and tumor-necrosis factor New food industry
Anti-tumor effect of heat-killed Enterococcus faecalis FK-23 in mice
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Yakugaku Zasshi
Biological response modifier activity of heat-killed Enterococcus faecalis FK-23
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Yakugaku Zasshi
Anti-hypertensive effect of Enterococcus faecalis FK-23 in spontaneously hypertensive rats Journal of Japanese of Nutrition and Food Science

Collaborators
Harvard University, Japan Red Cross Wakayama Medical Center, Kyoto University, Osaka City University, Nanjing Medical University, Ikeda Kaisei Hospital, Teikyo University, Miyazaki University, Mie University

List of patents
Patent on FK-23 Patent No. 3040711 Anti-tumor agent and its manufacturing process
Patent No. 3040699 Alleviation agent of toxicity
Patent No. 3272023 Therapeutic agent on leukocyte reduction
Patent No. 2712000 Therapeutic agent on hepatitis C
Patent No. 2969017 Protection agent on infection
Patent on LFK Patent No. 3040744 Anti-allergic agent and its manufacturing process
Patent No. 2944662 Therapeutic agent on rosacea
Patent No. 2889481 Anti-hypertensive agent
Patent No. 2889491 Anti-hypertensive agent